I use Lipo 6 with ephedrine and aspirin all the time. If it's your first time though, here's my advice. Cut the tablet in half. Take one Lipo 6 or Hydroxycut pill. Once you're used to it, work your way up. If I'm on the go, I'll often just get an ABB Speed Stack from GNC (250 mg caffeine and 25 g synephrine) to take my ephedrine and aspirin. But that's mostly because I sometimes get tired of drinking just water and it satisfies my taste fix without spiking my insulin.