Edwards (13-3) sports a three-fight win streak that includes victories over Vicente Luque, Albert Tumenov and Dominic Waters. The former BAMMA welterweight champion is 5-2 over his seven-fight UFC career.
Barberena (13-4) claimed his fourth Octagon win in six tries with a TKO of Joe Proctor earlier this year. He also earned a decision vs. Warlley Alves and finished both Sage Northcutt and Joe Ellenberger around defeats at the hands of Colby Covington and Chad Laprise.
The card takes place September 2 from the Ahoy Rotterdam and features heavyweights Stefan Struve and Alexander Volkov in the main event.